class ii mhc造句

Correlations may exist between polymorphisms within class II MHC promoters and autoimmune disease.
Class II MHC molecules have no ?2 subunits so can be recognised by CD4 co-receptors.
Helper T cells express T cell receptors ( TCR ) that recognize antigen bound to Class II MHC molecules.
By contrast, superantigens do not require processing by antigen-presenting cells but instead interact directly with the invariant region of the class II MHC molecule.
The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by isoform, have been identified.
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A number of glutamines and asparagines help bind short peptides ( with the PPII conformation ) in the groove of class II MHC ( Major Histocompatibility Complex ) proteins by forming these motifs.
"' Peptide binding for Class I and Class II MHC molecules "', showing the binding of peptides between the alpha-helix walls, upon a beta-sheet base.
Once at the lymph nodes, the APC begin to present antigen peptides that are bound to Class II MHC, allowing CD4 + T cells that express the specific TCRs against the peptide / MHC complex to activate.
In typical T-cell recognition, an antigen is taken up by an antigen-presenting cell, processed, expressed on the cell surface in complex with class II major histocompatibility complex ( MHC ) in a groove formed by the alpha and beta chains of class II MHC, and recognized by an antigen-specific T-cell receptor.
Their functions include signaling by BCR, modulation of that signaling by co-receptors, signaling by CD40, endocytosis of antigen bound to the BCR and its routing to late endosomes to facilitate loading of antigen-derived peptides onto class II MHC molecules, routing of those peptide / MHC-II complexes to the cell surface, and their participation in antigen presentation to T cells.